| Abstrakt: |
Simple Summary: The authors conducted this research to improve the prediction of how patients with esophageal cancer respond to a treatment called neoadjuvant chemoradiotherapy, which can enhance survival rates. However, doctors struggle to accurately predict how well a patient will respond to this treatment using existing imaging methods. To address this, the researchers developed a computer-based method called DCRNet, that not only analyzes medical images but also considers the distribution of radiation therapy doses on the radiotherapy treatment plans to make more accurate predictions. They tested this method on 80 patients with esophageal cancer and found that the HRNetV2p model with DCR performed the best, significantly improving prediction accuracy compared to other models. This breakthrough has the potential to help doctors better anticipate patient responses to treatment, which could lead to more personalized and effective care, and improving the treatment planning of radiotherapy. Esophageal cancer is a deadly disease, and neoadjuvant chemoradiotherapy can improve patient survival, particularly for patients achieving a pathological complete response (ypCR). However, existing imaging methods struggle to accurately predict ypCR. This study explores computer-aided detection methods, considering both imaging data and radiotherapy dose variations to enhance prediction accuracy. It involved patients with node-positive esophageal squamous cell carcinoma undergoing neoadjuvant chemoradiotherapy and surgery, with data collected from 2014 to 2017, randomly split into five subsets for 5-fold cross-validation. The algorithm DCRNet, an advanced version of OCRNet, integrates RT dose distribution into dose contextual representations (DCR), combining dose and pixel representation with ten soft regions. Among the 80 enrolled patients (mean age 55.68 years, primarily male, with stage III disease and middle-part lesions), the ypCR rate was 28.75%, showing no significant demographic or disease differences between the ypCR and non-ypCR groups. Among the three summarization methods, the maximum value across the CTV method produced the best results with an AUC of 0.928. The HRNetV2p model with DCR performed the best among the four backbone models tested, with an AUC of 0.928 (95% CI, 0.884–0.972) based on 5-fold cross-validation, showing significant improvement compared to other models. This underscores DCR-equipped models' superior AUC outcomes. The study highlights the potential of dose-guided deep learning in ypCR prediction, necessitating larger, multicenter studies to validate the results. [ABSTRACT FROM AUTHOR] |
