Effect of Clemastine on Neurophysiological Outcomes in an Ovine Model of Neonatal Hypoxic-Ischemic Encephalopathy.
| Autor: | Mike, Jana Krystofova, White, Yasmine, Hutchings, Rachel S., Vento, Christian, Ha, Janica, Iranmahboub, Ariana, Manzoor, Hadiya, Gunewardena, Anya, Cheah, Cheryl, Wang, Aijun, Goudy, Brian D., Lakshminrusimha, Satyan, Long-Boyle, Janel, Fineman, Jeffrey R., Ferriero, Donna M., Maltepe, Emin |
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| Předmět: |
STATISTICAL power analysis
SHEEP ANALYSIS of variance HETEROCYCLIC compounds ANIMAL experimentation ONE-way analysis of variance HEALTH outcome assessment MANN Whitney U Test TREATMENT effectiveness ARTIFICIAL respiration T-test (Statistics) DESCRIPTIVE statistics RESEARCH funding BRAIN injuries STATISTICAL sampling DATA analysis software PATIENT safety |
| Zdroj: | Children; Nov2023, Vol. 10 Issue 11, p1728, 16p |
| Abstrakt: | Originally approved by the U.S. Food and Drug Administration (FDA) for its antihistamine properties, clemastine can also promote white matter integrity and has shown promise in the treatment of demyelinating diseases such as multiple sclerosis. Here, we conducted an in-depth analysis of the feasibility, safety, and neuroprotective efficacy of clemastine administration in near-term lambs (n = 25, 141–143 days) following a global ischemic insult induced via an umbilical cord occlusion (UCO) model. Lambs were randomly assigned to receive clemastine or placebo postnatally, and outcomes were assessed over a six-day period. Clemastine administration was well tolerated. While treated lambs demonstrated improvements in inflammatory scores, their neurodevelopmental outcomes were unchanged. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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