| Autor: |
Xu, Hongtao, Fang, Fang, Wu, Kaizhang, Song, Jiangping, Li, Yaqian, Lu, Xingyu, Liu, Juncheng, Zhou, Liuyang, Yu, Wenqing, Yu, Fei, Gao, Jie |
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| Zdroj: |
Microbiome; 11/25/2023, Vol. 11 Issue 1, p1-16, 16p |
| Abstrakt: |
Background: Diet-induced dyslipidemia is linked to the gut microbiota, but the causality of microbiota-host interaction affecting lipid metabolism remains controversial. Here, the humanized dyslipidemia mice model was successfully built by using fecal microbiota transplantation from dyslipidemic donors (FMT-dd) to study the causal role of gut microbiota in diet-induced dyslipidemia. Results: We demonstrated that FMT-dd reshaped the gut microbiota of mice by increasing Faecalibaculum and Ruminococcaceae UCG-010, which then elevated serum cholicacid (CA), chenodeoxycholic acid (CDCA), and deoxycholic acid (DCA), reduced bile acid synthesis and increased cholesterol accumulation via the hepatic farnesoid X receptor-small heterodimer partner (FXR-SHP) axis. Nevertheless, high-fat diet led to decreased Muribaculum in the humanized dyslipidemia mice induced by FMT-dd, which resulted in reduced intestinal hyodeoxycholic acid (HDCA), raised bile acid synthesis and increased lipid absorption via the intestinal farnesoid X receptor-fibroblast growth factor 19 (FXR-FGF19) axis. Conclusions: Our studies implicated that intestinal FXR is responsible for the regulation of lipid metabolism in diet-induced dyslipidemia mediated by gut microbiota-bile acid crosstalk. 27dVNVWG4xVHYhT6VNwbbK Video Abstract [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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