| Autor: |
Zavala, Michael, Becker, Greta L., Lenth, Ron, Wels, Brian, Kahler, Justin, Schueller, Michael, Reisinger, Heather, Blount, Robert J. |
| Zdroj: |
Toxicology & Environmental Health Sciences; Dec2023, Vol. 15 Issue 4, p325-333, 9p |
| Abstrakt: |
Objective: An estimated 450,000 rural Iowans depend on private wells for their drinking water, and eight percent of those wells are contaminated with arsenic above federal limits. High arsenic concentrations are associated with chronic lung disease, yet the effects on lung disease in the Midwestern United States remain unclear. We hypothesize that (1) Well water arsenic concentrations are associated with urinary arsenic concentrations, and (2) Arsenic exposures are associated with lung function impairment among well users. Methods: We designed a cross-sectional pilot study in four rural Iowan counties. We collected kitchen-sink water, urine from each participant, and administered questionnaires. We analyzed water and urine arsenic concentrations using inductively coupled plasma mass spectrometry (ICP-MS); and liquid chromatography ICP-MS for detecting urinary arsenic metabolites. Spirometry was performed according to American Thoracic Society guidelines. We fit regression models to evaluate the association between arsenic exposure, measured by private well water and urinary arsenic concentration, and obstructive lung disease. Results: We enrolled 34 participants from 19 households. Water arsenic was significantly associated urinary arsenic concentrations. Every 1 µg/L increase in well water arsenic concentration predicted a 1.07 µg/L increase in urinary arsenic concentration (95% CI 0.47–1.67, p = 0.001). We found detectable arsenic concentrations in 42% of household well water samples and 94% of participant urine samples. We found no statistically significant associations between private well water arsenic concentration or urinary arsenic concentration and obstructive airway disease. Conclusion: Private well water arsenic concentrations were positively associated with participant urinary arsenic concentrations, whereas rice consumption was not, suggesting that well water is a significant source for arsenic exposure among rural Iowans. Larger prospective studies are needed to assess the interrelationships between rural drinking water pollutants (such as heavy metals, pesticides, and nitrates) and chronic respiratory disease. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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