| Autor: |
Shinde, Rahul B., Pansare, Dattatraya N., Shelke, Rohini N., Bangal, Mukund N., Sarkate, Aniket P., Tiwari, Shailee V., Kamble, Dhanraj, Chavan, Pravin, Zine, Ashok M. |
| Předmět: |
|
| Zdroj: |
Russian Journal of Bioorganic Chemistry; Nov2023, Vol. 49 Issue 6, p1398-1407, 10p |
| Abstrakt: |
A simplistic synthesis of (Z)-5-((substituted-2-(substituted phenyl)quinolin-3-yl)methylene)-2-thioxothiazolidin-4-one derivatives has been accomplished by employing acetic acid as the solvent and sodium acetate as the catalyst. We used the Suzuki-Miyaura cross coupling reaction to create carbon-carbon bonds. Our method is practical and has many benefits, such as a quicker reaction time and a higher yield under reflux conditions. For their anticancer and antibacterial activities, all produced compounds were described and tested. Compounds are some of these (IVa), (IVb), and (IVc) manifest significant antimicrobial activity. The compounds (IVe), (IVf), (IVg), and (IVh) show prominent antifungal activity. The compounds (IVi), (IVj), (IVk), and (IVl) against the breast cancer cell lines MCF-7 and MCF-10A, demonstrates strong anticancer activity. These findings imply that the rhodanine analogues might represent a fresh, potential model for anticancer and antibacterial medicines. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Full text from SpringerLink