| Autor: |
Peter, Martin F., Kalienkova, Valeria, Paulino, Cristina |
| Zdroj: |
BioSpektrum; Nov2023, Vol. 29 Issue 7, p721-724, 4p |
| Abstrakt: |
The sperm-specific Na+/H+ exchanger SLC9C1 stands out by its unique tripartite domain composition. It is the first known secondary-active transporter which is directly activated by membrane voltage via a voltage-sensing domain (VSD). Our cryo-EM structures of sea urchin SLC9C1 reveal the domain arrangement and new structural coupling elements, allowing us to propose a mechanism for a voltage-activated alternative access mechanism. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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