| Autor: |
Xu, Xiaodan, Wang, Xueting, Ding, Meiyun, Zhao, Yilin, Zhao, Li, Zhao, Linsheng, Li, Mengdi, Zhao, Fangyuan, Sun, Rongjuan, Wang, Zhiru, Zhang, Ruifeng, Zhang, Shujian, Ge, Liang, Sun, Yan, Zhan, Jianghua |
| Předmět: |
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| Zdroj: |
BMC Pediatrics; 11/23/2023, Vol. 23 Issue 1, p1-11, 11p |
| Abstrakt: |
Objectives: To validate an appropriate evaluation method of liver fibrosis assessment based on the unique pathological features of biliary atresia (BA) that could well predict its prognosis. Methods: A total of 68 patients with BA who underwent Kasai procedure (KP) and an intraoperative liver biopsy, followed up from January 2019 to December 2021, were recruited in a retrospective analysis. Ishak, Metavir, and BA-specific staging systems in relation to outcomes were analyzed using logistic regression, COX proportional hazard regression, Kaplan-Meier analysis, etc. Results: Kaplan-Meier analysis determined a significant difference in native liver survival according to the BA-specific stage (p = 0.002). The ROC curve analysis for predicting prognosis showed that the AUC of BA-specific staging combined with iBALF and severe bile duct proliferation (BDP) (0.811, 95% CI: 0.710–0.913, p < 0.0001) was higher than BA-specific staging alone (0.755, 95% CI: 0.639–0.872, p < 0.001). Conclusions: The BA-specific staging system reflects the condition of the liver fibrosis, and its combination with iBALF and severe BDP helps to better evaluate the prognosis of patients with BA. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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