Effects of NAD+ precursors on blood pressure, C‐reactive protein concentration and carotid intima‐media thickness: A meta‐analysis of randomized controlled trials.

Autor: Lei, Langhuan, Zhang, Xiaoli, Lin, Jiali, Liang, Qiuyu, Sohouli, Mohammad Hassan, Izze da Silva Magalhães, Elma, Fatahi, Somaye, Yang, Lihua, Xu, Wanting, Wang, Xingyong, Li, Wei, Yang, Jianrong
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Zdroj: European Journal of Clinical Investigation; Dec2023, Vol. 53 Issue 12, p1-11, 11p
Abstrakt: Background: There are contradictory effects regarding the effect of NAD+ precursor on blood pressure and inflammation. In order to obtain a better viewpoint from them, this study aimed to comprehensively investigate the effects of NAD+ precursor supplementation on blood pressure, C‐reactive protein (CRP) and carotid intima‐media thickness (CIMT). Methods: PubMed/MEDLINE, Web of Science, SCOPUS and Embase databases were searched using standard keywords to identify all controlled trials investigating the effects of NAD+ precursor on blood pressure, CRP and CIMT. Pooled weighted mean difference (WMD) and 95% confidence intervals (95% CI) were achieved by random‐effects model analysis for the best estimation of outcomes. Results: Twenty‐nine articles (with 8664 participants) were included in this article. Results from meta‐analyses of RCTs from random‐effects models indicated a significant reduction in systolic (SBP) (weighted mean difference (WMD): −2.54 mmHg, p <.001) and diastolic blood pressure (DBP) (WMD: −2.15 mmHg, p <.001), as well as in CRP (WMD: −.93 mg/L, 95% CI −1.47 to −.40, p <.001) concentrations and CIMT (WMD: −.01 mm, 95% CI −.02 to −.00, p =.005) with the NAD+ precursors supplementation compared with the control group. In addition, a greater effect of supplementation with NAD+ precursors in reducing blood pressure (BP) were observed with the highest dose (≥2 g) and duration of the intervention (>12 weeks), as well as with NA supplementation when compared to NE. Conclusions: Overall, these findings suggest that NAD+ precursor supplementation might have a beneficial effect on cardiovascular risk factors such as BP, CRP concentration and CIMT. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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