| Abstrakt: |
A recent study conducted at Nankai University in Tianjin, China, has shed light on the mechanisms by which major bacterial pathogens causing meningitis are able to cross the blood-brain barrier (BBB) and reach the brain. The researchers found that Streptococcus pneumoniae, group B Streptococcus, and neonatal meningitis Escherichia coli exploit a unique vesicle fusion mechanism to hitchhike on transferrin receptor transcytosis and penetrate the BBB. Toll-like receptor signals trigger a modification of the innate immune regulator TRAF3, leading to the formation of a protein complex that facilitates bacterial penetration of the BBB. This research provides valuable insights into the pathogenesis of meningitis and could potentially inform the development of new therapeutic strategies. [Extracted from the article] |
