| Abstrakt: |
A study conducted at Columbia University in New York City has found that ketogenesis, the production of ketone bodies in response to infection, promotes tolerance to Pseudomonas aeruginosa pulmonary infection. The researchers used a mouse model of pneumonia to demonstrate that ketone bodies generated in the liver circulate to the lungs and impose selection for P. aeruginosa strains that are unable to display surface lipopolysaccharide (LPS). These keto-adapted strains do not activate tissue-damaging cytokines and instead facilitate the catabolism of fats and oxidative phosphorylation, which helps maintain respiratory integrity. The study suggests that this environment enables coexistence between the host and P. aeruginosa, supporting both pathoadaptive changes in the bacteria and respiratory homeostasis. [Extracted from the article] |
