β-Cyclodextrins bearing ethylene glycol chains at their primary side: their preparations and evaluation as solubilizing agents for 17-β-estradiol and nuclear magnetic resonance structural analysis of a 17-β-estradiol inclusion complex.

Autor: Oda, Yoshiki, Nakagawa, Junki, Kasturaya, Kaname, Yamanoi, Takashi
Zdroj: Journal of Inclusion Phenomena & Macrocyclic Chemistry; Dec2023, Vol. 103 Issue 11/12, p421-428, 8p
Abstrakt: In this study, we designed and prepared two new β-cyclodextrins (1 and 2) bearing ethylene glycol chains to develop highly water-soluble cyclodextrins. They had excellent water solubility and could successfully dissolve 17-β-estradiol in water, which was considered a poorly soluble drug model. Additionally, the nuclear magnetic resonance structural analysis of a mixed sample of 17-β-estradiol and 1 in D2O–H2O suggested two different types of inclusion complexes with different 17-β-estradiol molecule orientations inside the cavity of 1. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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