| Autor: |
H., Sumaya, Saleh, Sameer Hazar S. |
| Předmět: |
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| Zdroj: |
Journal of College of Education for Pure Science; Sep2023, Vol. 13 Issue 3, p236-243, 8p |
| Abstrakt: |
Hyperprolactinemia status is commonly known as abnormal levels of prolactin hormone in the blood due to endocrine disorder. So far, there is no evidence explaining whether hyperprolactinemia affected Pancreas gland and vitamin D level in male. Therefore, this study aimed to eliminate hyperprolactinemia affecting the Pancreas gland by treating it with vitamin D supplements. Eighteen male rats were equally divide into three groups: The first group (6 rats): received normal saline for 42 days. The second group (6 rats): rats were given 5 mg/kg metoclopramide by intraperitoneal injection for hyperprolactinemia induction for 14 days. The third group (6 rats): hyperprolactinemic rats received 2.5 mg/kg vitamin D3 for 28 days. After the end of experimental) 42days(,hormonal parameters (prolactin, insulin, and vitamin D3) were measure, and the Pancreas gland was remove for routine paraffin-embedded section staining with hematoxylin and eosin staining. The result of the study revealed a significant decrease (P≤0. 01) in prolactin hormone concentration and a significant increase (P≤0. 01) in D3 concentration and insulin hormone Group 3compared with Group2. Histological examination of parts of the pancreas gland treated with vitamin D showed a remarkable recovery in the size and number of cells, and the cells became abundant in the cytoplasm. It was also noted that the nuclei returned to a size close to normal and took on a regular, spherical shape and central location compared to the hyperprolactinemia group. The study concluded that vitamin D had a protective effect on Pancreas gland by stabilizing insulin hormone level and restoration histological architectures throughout pancreas gland. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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