| Autor: |
Ushio, Y, Wakiya, R, Kameda, T, Nakashima, S, Shimada, H, Miyagi, T, Sugihara, K, Mino, R, Mizusaki, M, Chujo, K, Kagawa, R, Yamaguchi, H, Yamamoto, Y, Norikane, T, Nishiyama, Y, Kadowaki, N, Dobashi, H |
| Předmět: |
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| Zdroj: |
Scandinavian Journal of Rheumatology; Nov2023, Vol. 52 Issue 6, p710-712, 3p |
| Abstrakt: |
This article discusses the use of anti-interleukin-17 treatment in a case of ankylosing spondylitis (AS), a chronic inflammatory disease that primarily affects the spinal joints. The formation of new bone is a hallmark of advanced AS, leading to loss of flexibility in the vertebrae. The study used 18F-sodium fluoride positron emission tomography/computed tomography (PET/CT) to assess osteoblastic activity before and after treatment with an interleukin-17 inhibitor (IL-17i). The results showed a decrease in osteoblastic activity and new bone formation after treatment, indicating the effectiveness of IL-17i in reducing abnormal bone growth in AS. The study suggests that 18F-NaF PET/CT may be a useful tool for evaluating disease activity in AS. However, the use of this imaging modality may be limited due to increased radiation exposure compared to conventional methods, and further validation in larger patient populations is needed. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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