| Autor: |
Tabarsaei, Navisa, Sayyed-Alangi, S. Zahra, Varasteh-Moradi, Ali, Hossaini, Zinatossadat, Zafar Mehrabian, Ramin |
| Předmět: |
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| Zdroj: |
Polycyclic Aromatic Compounds; 2023, Vol. 43 Issue 10, p9087-9104, 18p |
| Abstrakt: |
A green protocol for diastereoselective synthesis of trans-trans-1H-Chromeno[2,3-d]pyrimidine-2,4,6(3H)-trione was applied by tandem aldol-Michael reactions between 1,3-dimethylbarbituric acid, aldehydes, and dimedone at room temperature on the water as well as the present of KF/Stilbite nanoparticles. Also, the catalytic activity of the nanocatalyst (NC) was evaluated in the reduction of organic pollutants such as 4-nitrophenol (4-NP) in water at mild conditions. The results indicated that the NCs have very high and effective catalytic activity for organic pollutants within a few seconds. Antioxidant abilities of synthesized compounds were revealed using radical trapping of diphenyl-picrylhydrazine (DPPH) and ferric reduction power experiments. The compounds 4a–d had excellent DPPH• radical scavenging. Also, the antimicrobial activity of some synthesized compounds was proved by employing the disk diffusion test on Gram-positive and Gram-negative bacteria. Synthesis of diastereomer derivatives is important in medicinal chemistry. This research was designed for easy synthesis of diastereoisomer derivatives of 1H-chromeno[2,3-d]pyrimidine-2,4,6(3H)-triones. The heterocyclic compounds have a recognized subject due to having a wide range of medicinal properties. The synthesized compounds revealed biological activities. Zeolites have cation replacement. Stilbite (ST), a natural zeolite with a framework structure and high internal surface area, is more effective because of its exchange capability for cations particularly for Na+ and Ca2+. Therefore, stilbite was used as a catalyst. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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