| Autor: |
ZHANG Dongxu, ZHAO Xinhua, JIANG Huanying, ZHOU Lixin, SUN Zhongren, YIN Hongna |
| Předmět: |
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| Zdroj: |
Journal of Practical Medicine / Shiyong Yixue Zazhi; 10/25/2023, Vol. 39 Issue 20, p2676-2682, 7p |
| Abstrakt: |
Spinal cord injury (SCI) is a serious disease of the central nervous system (CNS), which often leads to motor dysfunction and is associated with a variety of serious complications, seriously affecting the quality of life of patients. N6-methyladenosine (m6A) is a methylation modification that occurs at the N6 site of adenos- ine, also known as the m6A methylation modification, which is of great interest because of its great potential for diagnosis and treatment of neurological diseases. m6A modifications are catalyzed by methyltransferases, removed by demethylases, recognized by methyl-recognition proteins, and its associated regulatory proteins can affect the development of SCI and its secondary damage through various pathways. Up to now, the mechanism of m6A modi- fication in SCI has not been fully elucidated. In this paper, we review the basic functions of m6A modification and its role and mechanism in SCI. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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