| Abstrakt: |
Objective To use resting-state functional magnetic resonance imaging (rs-fMRI) to study ampli- tude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) changes in brain function in patients with anti-N-methyl-D-aspartate receptor encephalitis with cognitive impairment (ANMDARE-CI). Methods A total of 33 patients with anti-N-methyl-D-aspartate receptor encephalitis (ANMDARE) and 18 healthy volunteers (Controls) underwent rs-fMRI, the Beijing version of the Montreal Cognitive Assessment (MoCA-B) and neuropsychological scales. The cognitively impaired (ANMDARE-CI, n = 17) and the cognitively normal (ANMDARE-CN, n = 16) were divided according to the assessment of the MoCA-B scale. Differences in brain activity between the ANMDARE-CI, ANMDARE-CN and control were analysed using ReHo and ALFF. One-way ANOVA was performed using SPM12, ReHo and ALFF values for differential brain regions were extracted for independent samples t-tests for two-way comparisons and correlation analysis between clinical data and ANMDARE scales. Results Compared with AN- MDARE-CN and Control, in ANMDARE-CI,ALFFs of bilateral cerebellar were reduced, and the right superior fron- tal gyrus and left central anterior gyrus ALFF were increased (P < 0.01). Compared to Controls, in ANMDARE-CI and ANMDARE-CN, ALFFs of bilateral thalamus and ReHo of the right anterior cerebellar lobe were decreased (P < 0.01). ReHo of Left Anterior Cingulate in ANMDARE-CN was significantly lower than ANMDARE-CI and Controls (P < 0.01). Increased ALFF values on the right superior frontal gyrus were inversely correlated with MoCA-B performance scores (r = -0.586, P = 0.013). Increased left central anterior gyrus ALFF was negatively correlated with the MoCA-B directional score (r = -0.668, P = 0.003) and positively correlated with HAMA (r = 0.665, P = 0.004). No correlation between ReHo values and clinical data was found (P > 0.016). Conclusions Abnormal brain function in ANMDARE_CI may be associated with altered spontaneous cerebellar activity. [ABSTRACT FROM AUTHOR] |
