| Autor: |
Marchese, Silvia Maria, Palesi, Fulvia, Nigri, Anna, Bruzzone, Maria Grazia, Pantaleoni, Chiara, Wheeler-Kingshott, Claudia A. M. Gandini, D'Arrigo, Stefano, D'Angelo, Egidio, Cavallari, Paolo |
| Předmět: |
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| Zdroj: |
Frontiers in Neurology; 2023, p1-8, 8p |
| Abstrakt: |
Introduction: Within Pediatric Cerebellar Ataxias (PCAs), patients with nonprogressive ataxia (NonP) surprisingly show postural motor behavior comparable to that of healthy controls, differently to slow-progressive ataxia patients (SlowP). This difference may depend on the building of compensatory strategies of the intact areas in NonP brain network. Methods: Eleven PCAs patients were recruited: five with NonP and six with SlowP. We assessed volumetric and axonal bundles alterations with a multimodal approach to investigate whether eventual spared connectivity between basal ganglia and cerebellum explains the different postural motor behavior of NonP and SlowP patients. Results: Cerebellar lobules were smaller in SlowP patients. NonP patients showed a lower number of streamlines in the cerebello-thalamo-cortical tracts but a generalized higher integrity of white matter tracts connecting the cortex and the basal ganglia with the cerebellum. Discussion: This work reveals that the axonal bundles connecting the cerebellum with basal ganglia and cortex demonstrate a higher integrity in NonP patients. This evidence highlights the importance of the cerebellum-basal ganglia connectivity to explain the different postural motor behavior of NonP and SlowP patients and support the possible compensatory role of basal ganglia in patients with stable cerebellar malformation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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