| Abstrakt: |
The brain is exposed to the attack of reactive oxygen and nitrogen radicals due to its richness in lipid molecules and high oxygen consumption. The harmful effects of highly reactive radicals with unpaired electron balance on cells are reduced or destroyed by antioxidant enzymes and molecules, but when this balance is disrupted in favor of oxidant molecules, oxidative stress occurs. In psychiatric diseases, including obsessivecompulsive disorder, infiltration of peripheral immune cells into the central nervous system, disorders in serotonin, dopamine, glutamate metabolism, disruption of the kynurenine/tryptophan ratio and oxidative stress conditions in the cell can cause chronic inflammation (Wang et al. 2015; Marazati et al.2018). Paraoxonase (PON) is an enzyme with antioxidant and antiinflammatory capacity that can detoxify xenobiotics such as organophosphates carried by high-density lipoproteins that protect against atherogenesis (Ozdemir et al 2019). We wanted to examine the role of TNF-α and IL-6 pro-inflammatory cytokines, PON1 enzyme activities with antioxidant properties, and superoxide dismutase enzyme (SOD) activities, in the pathology of the disease in OCD. In our study, 100 patients diagnosed with OCD and 50 healthy people without neuropsychiatric disease constitute our control group. Serum TNF-α, IL-6 and activities of SOD were determined Enzyme linked Immunosorbent Assay. PON1 activities were assayed kinetically as the measurement of the linear increase of absorbance of p-nitrophenol. We found that TNF-α (p<0.001) as a pro-inflammatory cytokine was significantly increased in the OCD group, and the activities of PON1 (p<0.05) and SOD (p<0.001) were decreased. In conclusion, we can suggest that increased pro inflammatory cytokines and the decrease in antioxidant PON1 and SOD enzymes have important roles in the pathogenesis of OCD disease. [ABSTRACT FROM AUTHOR] |
