| Abstrakt: |
A recent report from Johns Hopkins University School of Medicine explores the role of the extracellular matrix (ECM) in breast cancer metastasis. The study found that primary breast tumors induce remodeling of the ECM in the premetastatic lungs, which can facilitate metastasis by increasing collagen levels, disrupting basement membranes, and promoting the formation of leaky blood vessels. The research was conducted using in vitro models and in vivo experiments with mice. These findings contribute to our understanding of the mechanisms involved in breast cancer metastasis and may have implications for the development of targeted therapies. [Extracted from the article] |
