Abstrakt: |
The patent application titled "Methods For Identification of Cognate Pairs of Ligands and Receptors" discusses the need for efficient methods to identify T cell antigens and B cell repertoires in cancer immunology. The inventors propose a method that involves screening thousands of antigens to identify pairs of ligands and receptors. This method can be applied to various types of binding pairs, including viral, bacterial, and parasitic antigens. The invention also has potential applications in cell therapy and the development of preventive and treatment vaccines. The method involves contacting ligand and receptor species in a microreactor and detecting enhanced signals upon selective binding. It can be used to study T cell activation, B cell activation, and other cellular processes. [Extracted from the article] |