| Abstrakt: |
A recent study conducted by investigators from Brigham and Women's Hospital in Cambridge, Massachusetts focuses on the development of muscle connective tissue layered myofibers through the use of stem cell fate-controlling biomaterials. The researchers explore the role of transforming growth factor-beta 1 (TGF-beta 1) and its inhibitor, as well as 3D matrix stiffness, in achieving co-differentiation of connective tissue fibroblasts and myofibers. By using bioengineering techniques such as photolithography and co-axial wet spinning, the researchers successfully create MCT-layered functional myofibers in 3D constructs. This research has potential applications in the development of biomimetic human muscle grafts for various biomedical purposes. [Extracted from the article] |
