| Abstrakt: |
Researchers at the Sepuluh Nopember Institute of Technology in Surabaya, Indonesia, have synthesized and tested cinnamamides for their alpha-glucosidase inhibitory activity. Nine of the synthesized cinnamamides displayed moderate inhibitory activity, outperforming acarbose. The structure of the cinnamamides greatly influenced their inhibitory activity, with electron-withdrawing groups on the cinnamoyl aromatic ring leading to increased inhibition. Compound 3b, with p-dimethylamino on the cinnamoyl ring, showed the best inhibitory activity and exhibited acceptable physicochemical and pharmacokinetics characteristics. These cinnamamides have potential as lead structures for further optimization as alpha-glucosidase inhibitors. [Extracted from the article] |
