| Abstrakt: |
Researchers from Scripps Research in La Jolla, California have made significant progress in understanding the anti-cancer activity of marine-derived cyclic imine toxins called portimines. These toxins have shown potential as therapeutic agents for cancer treatment, but their availability in large quantities has been a challenge. Through a scalable synthesis method, the researchers were able to produce portimines and their analogues, allowing for further investigation of their anti-cancer properties. The study revealed that portimine A selectively induces apoptosis in human cancer cells and is effective in tumor-clearance models. The primary target of portimine A was identified as the 60S ribosomal export protein NMD3. This research provides valuable insights into the potential use of portimines as anti-cancer agents. [Extracted from the article] |
