| Abstrakt: |
Researchers from Pennsylvania State University College of Medicine have conducted a study on the role of H-ferritin genetic manipulation in glioblastomas (GBM), a type of brain tumor. The study found that reducing systemic levels of the FTH1 protein, which is involved in iron transport, had a sexually dimorphic impact on survival. Female mice with reduced FTH1 levels had significantly poorer survival compared to control females, while the genetic manipulation also affected tumor infiltration of immune and stromal cells in a sexually dimorphic manner. These findings suggest a role for FTH1 and iron status in establishing the tumor cellular landscape and may inform population studies on the prevalence of brain tumors. [Extracted from the article] |
