EG-VEGF maternal levels predict spontaneous preterm birth in the second and third trimesters in pregnant women with risk factors for placenta-mediated complications.

Autor: Raia-Barjat, Tiphaine, Chauleur, Céline, Collet, Constance, Rancon, Florence, Hoffmann, Pascale, Desseux, Morgane, Lemaitre, Nicolas, Benharouga, Mohamed, Giraud, Antoine, Alfaidy, Nadia
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Zdroj: Scientific Reports; 11/14/2023, Vol. 13 Issue 1, p1-6, 6p
Abstrakt: Prediction of spontaneous preterm birth in asymptomatic women remains a great challenge for the public health system. The aim of the study was to determine the informational value of EG-VEGF circulating levels for prediction of spontaneous preterm birth in the second and third trimesters in pregnant women at high risk for placenta-mediated complications. A prospective multicenter cohort study including 200 pregnant patients with five-serum sampling per patient. Women with spontaneous preterm birth have higher concentrations of serum EG-VEGF than uncomplicated patients at 24 weeks, 28 weeks and 32 weeks (p = 0.03, 0.02 and < 0.001). The areas under the curve reached 0.9 with 100% sensitivity at 32 weeks for the prediction of spontaneous preterm birth. Serum EG-VEGF concentrations could be considered as a reliable biomarker of spontaneous preterm birth in high-risk for placenta-mediated complications pregnant women. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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