Adherence to treatment and parents' perspective about effectiveness of melatonin in children with autism spectrum disorder and sleep disturbances.
Autor: | Sadeh, Hadar, Meiri, Gal, Zigdon, Dikla, Ilan, Michal, Faroy, Michal, Michaelovski, Analya, Sadaka, Yair, Dinstein, Ilan, Menashe, Idan |
---|---|
Předmět: |
CLINICAL drug trials
PARENT attitudes SLEEP quality STATISTICS PSYCHOLOGY of children with disabilities CONFIDENCE intervals PARENTS of children with disabilities RETROSPECTIVE studies CHILD behavior REGRESSION analysis FISHER exact test SLEEP disorders MELATONIN TREATMENT effectiveness SLEEP duration T-test (Statistics) AUTISM PSYCHOSOCIAL factors KAPLAN-Meier estimator DESCRIPTIVE statistics CHI-squared test PATIENT compliance DATA analysis software LONGITUDINAL method PROPORTIONAL hazards models CHILDREN |
Zdroj: | Child & Adolescent Psychiatry & Mental Health; 10/27/2023, Vol. 17 Issue 1, p1-9, 9p |
Abstrakt: | Objective: Melatonin is considered an effective pharmacological treatment for the sleep disturbances that are reported in > 50% of children with autism spectrum disorder (ASD). However, real-life data about the long-term course and effectiveness of melatonin treatment in children with ASD is lacking. Methods: In this retrospective cohort study, we assessed the adherence to melatonin treatment and parents' perspective of its effect on sleep quality and daytime behavior in children with ASD via a parental phone survey of children in the Azrieli National Center for Autism and Neurodevelopment Research (ANCAN) database. Cox regression analysis was used to assess the effect of key demographic and clinical characteristics on treatment adherence. Results: Melatonin was recommended for ~ 8% of children in the ANCAN database. These children were characterized by more severe symptoms of autism. The median adherence time for melatonin treatment exceeded 88 months, with the most common reason for discontinuation being a lack of effectiveness (14%). Mild side-effects were reported in 14% of children, and 86%, 54%, and 45% experienced improvements in sleep onset, sleep duration and night awakenings, respectively. Notably, melatonin also improved the daytime behaviors of > 28% of the children. Adherence to treatment was independently associated with improvements in night awakenings and educational functioning (aHR = 0.142, 95%CI = 0.036–0.565; and aHR = 0.195, 95%CI = 0.047–0.806, respectively). Conclusions: Based on parents' report, melatonin is a safe and effective treatment that improves both sleep difficulties and daily behavior of children with ASD. [ABSTRACT FROM AUTHOR] |
Databáze: | Complementary Index |
Externí odkaz: | |
Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |