| Autor: |
Thomas, Alyse, Yang, Weiguo, Wang, Catherine, Tipparaju, Sri Laasya, Chen, Guang, Sullivan, Brennan, Swiekatowski, Kylie, Tatam, Mahima, Gerfen, Charles, Li, Nuo |
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| Zdroj: |
Nature Communications; 11/14/2023, Vol. 14 Issue 1, p1-22, 22p |
| Abstrakt: |
Action selection occurs through competition between potential choice options. Neural correlates of choice competition are observed across frontal cortex and downstream superior colliculus (SC) during decision-making, yet how these regions interact to mediate choice competition remains unresolved. Here we report that SC can bidirectionally modulate choice competition and drive choice activity in frontal cortex. In the mouse, topographically matched regions of frontal cortex and SC formed a descending motor pathway for directional licking and a re-entrant loop via the thalamus. During decision-making, distinct neuronal populations in both frontal cortex and SC encoded opposing lick directions and exhibited competitive interactions. SC GABAergic neurons encoded ipsilateral choice and locally inhibited glutamatergic neurons that encoded contralateral choice. Activating or suppressing these cell types could bidirectionally drive choice activity in frontal cortex. These results thus identify SC as a major locus to modulate choice competition within the broader action selection network. Multiple cortical and subcortical brain regions are implicated in decision-making, yet their causal interactions remain unclear. Here, the authors identified cellular and circuit interactions that bias cortical decision-making dynamics and behavior. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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