Continuous-Flow Regioselective Reductive Alkylation of Oxindole with Alcohols and Aldehydes in a Fast and Economical Manner.

Autor: Mándoki, András, Orsy, György, Pászti, Zoltán, Porcs-Makkay, Márta, Bogdán, Dóra, Simig, Gyula, Mándity, István, Volk, Balázs
Předmět:
Zdroj: Synthesis; Dec2023, Vol. 55 Issue 23, p4025-4033, 9p
Abstrakt: This article explores the synthesis of oxindole derivatives, which are important compounds in organic and medicinal chemistry. The authors present a method for synthesizing these compounds using continuous-flow technology, which offers advantages over traditional batch methods. Through experimentation, the authors optimized the reaction parameters and achieved high conversion rates and yields. The results suggest that continuous-flow technology has the potential for large-scale production of oxindole derivatives in a fast and cost-effective manner. The article also discusses the synthesis of 3-alkyloxindoles through reductive alkylation, providing detailed experimental procedures and characterization data for the synthesized compounds. The research was supported by grants from the European Union. [Extracted from the article]
Databáze: Complementary Index