| Autor: |
Sungthong, Bunleu, Winyupan, Sirikran, Nunthaboot, Nadtanet, Phimarn, Wiraphol, Sripadung, Ployvadee |
| Předmět: |
|
| Zdroj: |
Tropical Journal of Natural Product Research; Oct2023, Vol. 7 Issue 10, p4262-4266, 5p |
| Abstrakt: |
Andrographolide (AP) is a sparingly water solubility bioactive compound from Andrographis paniculata. It exhibits several pharmacological activities. With respect to its hydrophobicity, the high-yield extract of AP is primarily obtained from organic solvents, which are considered as environmentally harmful substances. Therefore, the green extraction using an alternative solvent is eventually performed to obtain the highest AP extract. The objectives of this study are to investigate the extraction efficiency of AP using different types of cyclodextrins (CDs) in aqueous media and in silico molecular docking study of AP with the corresponding CDs. The cyclodextrinassisted extraction of AP using alpha cyclodextrin (αCD), beta cyclodextrin (βCD), gamma cyclodextrin (γCD), methyl beta cyclodextrin (MβCD), trimethyl beta cyclodextrin (triMβCD) and hydroxypropyl beta cyclodextrin (HPβCD) at a concentration of 1 mM was investigated in aqueous media comparing with water and methanol by ultrasonication. The amount of AP in each extract was determined by an HPLC method. In screening process, HPβCD exhibited the highest extraction yield of AP compared with the other CDs. However, it was significantly lower than that in the methanolic extract (P < 0.05). Subsequently, the extraction of AP was performed as a function of HPβCD concentration. Increasing the concentration of HPβCD resulted to obtain the better extraction yield of AP comparing with a positive control of methanol (P < 0.05). In conclusion, the green extraction using HPβCD could be an alternative method to achieve a higher AP in the extract than that in the methanolic extract. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
