The Influence of Chirality on the β-Amino-Acid Naphthalenediimides/G-Quadruplex DNA Interaction.

Autor:	Clowes, Samuel R., Ali, Yusuf, Astley, Olivia R., Răsădean, Dora M., Pantoş, G. Dan
Předmět:	CHIRALITY DNA MOLECULAR docking QUADRUPLEX nucleic acids CHIRAL recognition ENANTIOMERS
Zdroj:	Molecules; Nov2023, Vol. 28 Issue 21, p7291, 19p
Abstrakt:	G-quadruplexes (G4s) have been identified as a potential alternative chemotherapy target. A series of eight β-amino acid derived naphthalenediimides (NDI) were screened against a series of oncogenic G4 sequences: c-KIT1, h-TELO, and TBA. Three sets of enantiomers were investigated to further our understanding of the effect of point chirality on G4 stabilisation. Enantioselective binding behaviour was observed with both c-KIT1 and h-TELO. Docking studies using GNINA and UV-vis titrations were employed to better understand this selective binding behaviour. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.