| Autor: |
Sokolova, A. S., Baranova, D. V., Yarovaya, O. I., Zybkina, A. V., Mordvinova, E. D., Zaykovskaya, A. V., Baev, D. S., Tolstikova, T. G., Shcherbakov, D. N., Pyankov, O. V., Maksyutov, R. A., Salakhutdinov, N. F. |
| Předmět: |
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| Zdroj: |
Russian Chemical Bulletin; Oct2023, Vol. 72 Issue 10, p2536-2547, 12p |
| Abstrakt: |
A series of new (1S)-(+)-camphor-10-sulfonamides containing various substituents at the nitrogen atom were synthesized, and their antiviral properties against Ebola virus were evaluated using a vesicular stomatitis virus-based pseudovirus system. The reduction of the carbonyl group at the C(2) atom leads to a significant improvement in the antiviral efficacy, whereas the transformation into oxime results in the almost complete disappearance of antiviral activity. According to the evaluation of antiviral activity against natural Ebola virus, the lead compounds exhibit moderate inhibitory activity. Interactions of the lead compounds with the binding site of Ebola virus glycoprotein were studied by molecular modeling. A comparative analysis of the changes due to possible interactions of the synthesized ligands and known inhibitors with Ebola virus surface glycoprotein was carried out. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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