| Autor: |
SHOTA SHIMIZU, TOMOYUKI MATSUNAGA, YU SAKANO, MASAHIRO MAKINOYA, YUJI SHISHIDO, KOZO MIYATANI, YUSUKE KONO, YUKI MURAKAMI, TAKEHIKO HANAKI, KYOICHI KIHARA, MANABU YAMAMOTO, NARUO TOKUYASU, SHUICHI TAKANO, TERUHISA SAKAMOTO, TOSHIMICHI HASEGAWA, YOSHIYUKI FUJIWARA |
| Předmět: |
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| Zdroj: |
In Vivo; Nov/Dec2023, Vol. 37 Issue 6, p2662-2668, 7p |
| Abstrakt: |
Background/Aim: Preoperative osteopenia, defined as low bone mineral density, is a prognostic factor in patients with digestive tract cancers, including gastric cancer (GC). However, the correlation between preoperative osteopenia and GC in elderly patients is unclear. Patients and Methods: We enrolled 251 patients who had undergone curative surgery for histopathologically diagnosed gastric adenocarcinoma from January 2008 to December 2012. Patients were classified into the non-elderly group (n=169) and the elderly group (n=82). Bone mineral density was calculated as the average pixel density (Hounsfield units) within a circle of the mid-vertebral core at the bottom of the 11th thoracic vertebra on preoperative computed tomography. Results: Although overall survival was significantly shorter in the elderly compared to the nonelderly group (p=0.0062), there was no significant difference in disease-specific survival between the two groups (p=0.71) because of the higher rate of death from other diseases. In addition, the elderly group had a significantly higher incidence of osteopenia (p<0.001) and a significantly lower prognostic nutritional index (p<0.001). Multivariate analysis revealed that preoperative osteopenia and a low preoperative prognostic nutritional index were significant risk factors for death from other diseases after gastrectomy in elderly patients. Conclusion: In elderly patients with GC, preoperative osteopenia is an important factor to consider in terms of both curability and death from other diseases. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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