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| Zdroj: |
Hematology Week; 11/14/2023, p640-640, 1p |
| Abstrakt: |
A recent study conducted by researchers at the University of Michigan explored the role of myeloid Hif2a in maintaining systemic iron homeostasis. The study found that deleting Hif2a in macrophages did not disrupt the expression of iron transporters or basal erythropoiesis. Mice lacking Hif2a in myeloid cells showed no significant differences in hemodynamic parameters, indicating that the disruption of Hif2a in myeloid cells does not significantly impact systemic iron homeostasis under normal physiological conditions. However, the study did find that its disruption induces adaptive physiological changes in response to elevated iron demand. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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