Antiproliferative effects of D-allose associated with reduced cell division frequency in glioblastoma.

Autor: Suzuki, Kenta, Ogawa, Daisuke, Kanda, Takahiro, Fujimori, Takeshi, Shibayama, Yuki, Rahman, Asadur, Ye, Juanjuan, Ohsaki, Hiroyuki, Akimitsu, Kazuya, Izumori, Ken, Tamiya, Takashi, Nishiyama, Akira, Miyake, Keisuke
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Zdroj: Scientific Reports; 11/9/2023, Vol. 13 Issue 1, p1-9, 9p
Abstrakt: Recent studies have shown that D-allose, a rare sugar, elicits antitumor effects on different types of solid cancers, such as hepatocellular carcinoma, non-small-cell lung cancer, and squamous cell carcinoma of the head and neck. In this study, we examined the effects of D-allose on the proliferation of human glioblastoma (GBM) cell lines (i.e., U251MG and U87MG) in vitro and in vivo and the underlying mechanisms. D-allose treatment inhibited the proliferation of U251MG and U87MG cells in a dose-dependent manner (3–50 mM). However, D-allose treatment did not affect cell cycles or apoptosis in these cells but significantly decreased the cell division frequency in both GBM cell lines. In a subcutaneous U87MG cell xenograft model, intraperitoneal injection of D-allose (100 mg/kg/day) significantly reduced the tumor volume in 28 days. These data indicate that D-allose-induced reduction in cell proliferation is associated with a subsequent decrease in the number of cell divisions, independent of cell-cycle arrest and apoptosis. Thus, D-allose could be an attractive additive to therapeutic strategies for GBM. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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