| Autor: |
Pandey, Vivek, Punniyamoorthy, Shirani, Pokharel, Yuba Raj |
| Předmět: |
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| Zdroj: |
Cellular Physiology & Biochemistry (Cell Physiol Biochem Press GmbH & Co. KG); 2023, Vol. 57 Issue 5, p395-408, 16p |
| Abstrakt: |
Suppressor of Ty homolog-5 (SPT5) discovered in the yeast mutant screens as a suppressor of mutation caused by the insertion of the Transposons of yeast (Ty) element along with SPT4, with which it forms a holoenzyme complex known as DRB sensitivity-inducing factor (DSIF) and plays an essential role in the regulation of transcription. SPT5 is a highly conserved protein across all three domains of life and performs critical functions in transcription, starting from promoter-proximal pausing to termination. We also highlight the emerging role of SPT5 in other non-canonical functions, such as the regulation of post-translational modifications (PTM) and the transcriptional regulation of non-coding genes. Also, in brief, we highlight the clinical implications of SPT5 dysregulation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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