| Autor: |
Li, Hailong, McLaurin, Kristen A., Mactutus, Charles F., Rappaport, Jay, Datta, Prasun K., Booze, Rosemarie M. |
| Předmět: |
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| Zdroj: |
Molecular Biomedicine; 11/7/2023, Vol. 4 Issue 1, p1-4, 4p |
| Abstrakt: |
To evaluate the hypothesis, brain tissue from the pyriform cortex/amygdala was dual-labeled for SARS-CoV-2 mRNA and platelet-derived growth factor receptor beta (PDGFR ), a biomarker exclusively expressed in pericytes in the adult brain. Given the persistence of SARS-CoV-2 mRNA in the brain, advanced statistical approaches were utilized to evaluate whether the acute clinical disease phenotype was predictive of persistent brain infection in the pyriform cortex/amygdala. SARS-CoV-2 mRNA persists in the pyriform cortex (h) of non-human primates despite clinical recovery; no prominent fluorescent SARS-CoV-2 mRNA were observed in the pyriform cortex/amygdala of wildtype primates (g). Taken together, examination of post-mortem pyriform cortex/amygdala brain tissue of non-human primates clinically recovered from SARS-CoV-2 infection revealed two early pathophysiological mechanisms potentially underlying PASC. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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