Different benefits of adaptive radiotherapy for different histologies of NSCLC.

Autor:	Tvilum, Marie, Lutz, Christina Maria, Knap, Marianne Marquard, Hoffmann, Lone, Khalil, Azza Ahmed, Holt, Marianne Ingerslev, Kandi, Maria, Schmidt, Hjørdis Hjalting, Appelt, Ane L., Alber, Markus, Møller, Ditte S.
Předmět:	LUNG cancer COMPUTERS in medicine ADENOCARCINOMA CONFIDENCE intervals RETROSPECTIVE studies TREATMENT duration MANN Whitney U Test REGRESSION analysis DOSE-response relationship (Radiation) TREATMENT effectiveness TUMOR classification RADIATION pneumonitis PEARSON correlation (Statistics) RADIATION doses CHI-squared test KAPLAN-Meier estimator DESCRIPTIVE statistics RESEARCH funding RADIOTHERAPY DATA analysis software SQUAMOUS cell carcinoma PROPORTIONAL hazards models
Zdroj:	Acta Oncologica; Nov2023, Vol. 62 Issue 11, p1426-1432, 7p
Abstrakt:	Adenocarcinoma (AC) and squamous cell carcinoma (SCC) are the most frequent histological subtypes of non-small cell lung cancer (NSCLC). The aim of this study was to investigate how patients with AC and SCC benefit from image-guided adaptive radiotherapy (ART) with tumour match. Consecutive patients diagnosed with AC or SCC of the lung treated with definitive chemo-radiotherapy before and after the implementation of ART and tumour match were retrospectively included for analyses. Data collection included baseline patient and treatment characteristics in addition to clinical data on radiation pneumonitis (RP), failure, and survival. Patients were divided into four categories based on their histology and treatment before (n = 173 [89 AC and 84 SCC]) and after implementation of ART (n = 240 [141 AC and 99 SCC]). Median follow-up was 5.7 years for AC and 6.3 years for SCC. Mean lung dose decreased for both histologies with ART, whereas mean heart dose only decreased for patients with AC. Incidences of grade 3 and 5 RP decreased for both histologies with ART. Loco-regional failure (LRF) rates decreased significantly for patients with SCC after ART (p =.04), no significant difference was observed for AC. Overall survival (OS) increased significantly for SCC after ART (p <.01): the 2-year OS increased from 31.0% (95% confidence interval [CI] [22.5–42.6]) to 54.5% (95% CI [45.6–65.3]). No significant effect on OS was observed for patients with AC. ART and tumour match in the radiotherapeutic treatment of patients with locally advanced NSCLC primarily led to decreased LRF and improved OS for patients with SCC. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.