Electrochemical Three‐Component Reaction to Construct N‐(α‐alkoxyalkyl)benzotriazoles.

Autor:	Liu, Han‐Fu, Li, Yang, Wang, Guo‐Ao, Chen, Kai‐Wei, Tang, Hai‐Tao, Pan, Ying‐Ming, He, Mu‐Xue, Yang, Ke‐Di, Huang, Yong‐Lin
Předmět:	ANTINEOPLASTIC agents ALDEHYDES AZOLES
Zdroj:	Advanced Synthesis & Catalysis; 11/7/2023, Vol. 365 Issue 21, p3586-3590, 5p
Abstrakt:	N‐(α‐alkoxyalkyl)benzotriazoles are of great importance for biochemical and antitumor activity. A feasible protocol has been developed for the synthesis of N‐(α‐alkoxyalkyl)benzotriazoles using azoles, aldehydes and alcohols as substrates under electrochemical conditions. The reaction is carried out under acid catalyst‐ and oxidant‐free conditions, so that a variety of synthetically useful nitrogen heterocyclic derivatives can be obtained. More meaningfully, a gram‐scale synthetic approach was employed to demonstrate the scale‐up applicability of this transformation. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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