| Autor: |
Guan, Meng, Hou, Ming, Tang, Shuwang, Cheng, Guang, Zhu, Xinyu, Zhao, Yun-Hui, Tang, Ximei, Zhou, Hongwei, Qiu, Guanyinsheng |
| Předmět: |
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| Zdroj: |
Chemical Communications; 11/18/2023, Vol. 59 Issue 89, p13309-13312, 4p |
| Abstrakt: |
This study describes an iron-catalyzed divergent oxidation of styrene into β-hydroxylmethylketone and ketone under photo-irradiation. This divergence is ascribed to the use of styrene with various substituents. More importantly, methanol is oxidized into formaldehyde in the reaction and serves as a C1 synthon. Mechanism investigations show that the reaction is initiated by oxidative SET to transfer styrene into the cation radical. The reaction pathway undergoes HAT and β-hydride elimination as well as a concerted cyclization. Particularly, several drug-like molecules, such as melperone analogue, lenperone analogue, and haloperidol analogue, are synthesized. In addition, this method is also applicable to the synthesis of natural product (R)-atomoxetine. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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