Photoredox-catalyzed C-heteroaryl glycosylation of biphenyl isocyanides with glycosyl bromides.

Autor: Jiao, Yi, Shi, Xiaoran, Yu, Shouyun
Předmět:
Zdroj: Chemical Communications; 11/18/2023, Vol. 59 Issue 89, p13336-13339, 4p
Abstrakt: 8,9-Dimethoxyphenanthridine derivatives, as potential antitumor drugs, need modification to improve their biocompatibility and water solubility. Reported here is a strategy to access C-heteroaryl glycosides by photoredox catalysis. C6-glycosylated phenanthridine derivatives are synthesized from biphenyl isocyanides and glycosyl bromides. The reaction conditions are mild and widely applicable, with anomeric α selectivity and good functional group tolerance. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index