The impact of frailty evaluation on the risk of venous thromboembolism in patients with hip fracture following surgery: a meta-analysis.
| Autor: | Zhang, Haixia, Wu, Fang, Sun, Jianbin, Liu, Yongchao, Zhou, Zifu, Wu, Xuejun, Liang, Bin |
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| Předmět: |
THROMBOEMBOLISM risk factors
ONLINE information services MEDICAL databases FRAIL elderly VEINS META-analysis MEDICAL information storage & retrieval systems SCIENTIFIC observation CONFIDENCE intervals ORTHOPEDIC surgery SYSTEMATIC reviews HIP fractures SURGICAL complications DISEASE incidence RISK assessment COMPARATIVE studies THROMBOEMBOLISM MEDLINE ODDS ratio |
| Zdroj: | Aging Clinical & Experimental Research; Nov2023, Vol. 35 Issue 11, p2413-2423, 11p |
| Abstrakt: | Background: Frailty has been associated with a higher incidence of overall postoperative complications and mortality. However, the influence of frailty on the risk of venous thromboembolism (VTE) in patients with hip fracture following surgery remains unclear. We performed a meta-analysis to systematically evaluate the above association. Methods: PubMed, Embase, Cochrane Library, Wanfang and CNKI were searched for relevant observational studies comparing the incidence of postoperative VTE in patients of hip fracture with and without frailty. Data collection, literature searching, and statistical analysis were conducted independently by two authors. Using a heterogeneity-incorporating random-effects model, the results were pooled. Results: In this meta-analysis, 9509 patients from nine cohort studies were included. Pooled results showed that compared to those without frailty, patients with frailty at admission had a higher incidence of postoperative VTE (odds ratio [OR]: 2.59, 95% confidence interval [CI]: 1.25–5.39, p = 0.01; I2 = 66%). Subgroup analysis suggested the association between frailty and postoperative VTE was more remarkable in studies of patients with frailty prevalence < 50% (OR 6.28, 95% CI 3.31–11.90, p < 0.001; I2 = 8%) as compared to those ≥ 50% (OR 1.30, 95% CI 0.80–2.11, p = 0.28; I2 = 0%; p for subgroup difference < 0.001). Further meta-analyses showed that frailty at baseline was associated with a higher incidence of deep venous thrombosis (OR 3.15, 95% CI 1.33–7.47, p = 0.009; I2 = 59%), but not pulmonary embolism (OR 1.13, 95% CI 0.59–2.16, p = 0.72; I2 = 0%). Conclusion: Frailty is associated with a higher incidence of postoperative VTE in patients with hip fracture. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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