| Autor: |
Funiciello, Elisa, Mula, Jacopo, Mignone, Federica, Silvestro, Erika, Ragazzi, Paola, Pilloni, Giulia, Costa, Cristina, D'Avolio, Antonio, Garazzino, Silvia |
| Předmět: |
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| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); Nov2023, Vol. 78 Issue 11, p2776-2778, 3p |
| Abstrakt: |
In the last decades, the worldwide spread of difficult-to-treat (DTR) Gram-negative bacteria has prompted the use of newly approved antimicrobials with activity against MDR microorganisms, in particular carbapenem-resistant strains.[1] Bacterial meningitis is I per se i a severe infection, especially in the paediatric population and if MDR bacteria are involved.[2] We here describe the case of an infant successfully treated with cefiderocol for meningoencephalitis caused by DTR I Pseudomonas aeruginosa i . The patient completed 8 weeks of treatment with cefiderocol uneventfully with progressive improvement in MRI images and subsequent negative CSF culture results. CSF penetration of cefiderocol was 69.5%, higher than previously reported in adults,[10] probably due to the severity of the patient's clinical condition with a consequent high blood-brain barrier permeability. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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