Recent Research from University of New Haven Highlight Findings in Sickle Cell Anemia (Structure-based Computational Design of Novel Covalent Binders for the Treatment of Sickle Cell Disease).

Předmět:	SICKLE cell anemia BLOOD diseases UNIVERSITY research DRUG discovery
Zdroj:	Hematology Week; 11/6/2023, p2144-2144, 1p
Abstrakt:	Recent research from the University of New Haven has focused on the development of novel covalent binders for the treatment of sickle cell disease (SCD). The researchers used structure-based computational techniques to design random molecules based on the electrophilic functionality of the drug Voxelotor. Through virtual screening and molecular dynamics simulations, they identified three potential drug candidates with promising properties. However, further experimental validation is needed to determine their preclinical relevance for drug development. This research provides valuable insights into potential therapeutic targets for SCD. [Extracted from the article]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu