| Autor: |
Fernández-González, Marta, Agulló, Vanesa, García, José Alberto, Padilla, Sergio, García-Abellán, Javier, de la Rica, Alba, Mascarell, Paula, Masiá, Mar, Gutiérrez, Félix |
| Předmět: |
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| Zdroj: |
Journal of Infectious Diseases; 11/1/2023, Vol. 228 Issue 9, p1240-1252, 13p |
| Abstrakt: |
Background We measured T-cell and antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vaccinated patients hospitalized for coronavirus disease 2019 (COVID-19) and explored their potential value to predict outcomes. Methods This was a prospective, longitudinal study including vaccinated patients hospitalized with Delta and Omicron SARS-CoV-2 variants. TrimericS-IgG antibodies and SARS-CoV-2 T-cell response were measured using a specific quantitative interferon-γ release assay (IGRA). Primary outcome was all-cause 28-day mortality or need for intensive care unit (ICU) admission. Cox models were used to assess associations with outcomes. Results Of 181 individuals, 158 (87.3%) had detectable SARS-CoV-2 antibodies, 92 (50.8%) showed SARS-CoV-2–specific T-cell responses, and 87 (48.1%) had both responses. Patients who died within 28 days or were admitted to ICU were less likely to have both unspecific and specific T-cell responses in IGRA. In adjusted analyses (adjusted hazard ratio [95% confidence interval]), for the entire cohort, having both T-cell and antibody responses at admission (0.16 [.05–.58]) and Omicron variant (0.38 [.17–.87]) reduced the hazard of 28-day mortality or ICU admission, whereas higher Charlson comorbidity index score (1.27 [1.07–1.51]) and lower oxygen saturation to fraction of inspired oxygen ratio (2.36 [1.51–3.67]) increased the risk. Conclusions Preexisting immunity against SARS-CoV-2 is strongly associated with patient outcomes in vaccinated individuals requiring hospital admission for COVID-19. Persons showing both T-cell and antibody responses have the lowest risk of severe outcomes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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