| Autor: |
Benner, Sarah E, Zhu, Xianming, Hussain, Sarah, Florman, Sander, Eby, Yolanda, Fernandez, Reinaldo E, Ostrander, Darin, Rana, Meenakshi, Ottmann, Shane, Hand, Jonathan, Price, Jennifer C, Pereira, Marcus R, Wojciechowski, David, Simkins, Jacques, Stosor, Valentina, Mehta, Sapna A, Aslam, Saima, Malinis, Maricar, Haidar, Ghady, Massie, Allan |
| Předmět: |
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| Zdroj: |
Journal of Infectious Diseases; 11/1/2023, Vol. 228 Issue 9, p1274-1279, 6p |
| Abstrakt: |
The latent viral reservoir (LVR) remains a major barrier to HIV-1 curative strategies. It is unknown whether receiving a liver transplant from a donor with HIV might lead to an increase in the LVR because the liver is a large lymphoid organ. We found no differences in intact provirus, defective provirus, or the ratio of intact to defective provirus between recipients with ART-suppressed HIV who received a liver from a donor with (n = 19) or without HIV (n = 10). All measures remained stable from baseline by 1 year posttransplant. These data demonstrate that the LVR is stable after liver transplantation in people with HIV. Clinical Trials Registration. NCT02602262 and NCT03734393. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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