Synthesis, radiolabeling and in vitro evaluation of azathioprine loaded magnetic solid lipid nanoparticles.

Autor:	Türkkanı, Gökce, Güngör, Burcu, Cetin, Oğuz, İçhedef, Çiğdem, Parlak, Yasemin, Gümüşer, F. Gül, Sayıt Bilgin, B. Elvan, Teksöz, Serap
Předmět:	TARGETED drug delivery RADIOLABELING DRUG delivery systems AZATHIOPRINE LIPIDS NANOPARTICLES
Zdroj:	Journal of Radioanalytical & Nuclear Chemistry; Nov2023, Vol. 332 Issue 11, p4695-4704, 10p
Abstrakt:	In this study, it is aimed to design a smart drug delivery system for the diagnosis and treatment of cancer cells. Magnetic-solid lipid nanoparticles were synthesized as a drug delivery system and azathioprine (AZA) was loaded into this system. This newly created system was radiolabeled using technetium-99 m with a radiolabeling yield of 90.3%. Drug loading into the SLMNP was found as 86%. The biological behavior of 99mTc and radiolabeled magnetic solid lipid nanoparticles loaded with azathioprine (99mTc-AZA-SLMNP) was investigated in vitro and in vivo. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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