| Autor: |
Huynh Thanh, Long, Dao Bui Quy, Quyen, Nguyen Manh, Khiem, Nguyen Huu, Dung, Nguyen Trung, Kien, Le Viet, Thang |
| Zdroj: |
Health Science Reports; Oct2023, Vol. 6 Issue 10, p1-9, 9p |
| Abstrakt: |
Purpose: To determine the rate of acute kidney injury (AKI) after laparoscopic colorectal cancer (CRC) surgery and the predictive value of urine neutrophil gelatinase‐associated lipocalin (uNGAL) for postoperative AKI and mortality during 3 years of follow‐up. Methods: A total of 216 CRC patients who had undergone laparoscopic surgery were included in our study. We divided all patients into two groups, including group 1 (n = 31) with postoperative AKI and group 2 (n = 185) without postoperative AKI. Urine NGAL was measured using the ELISA technique. Clinical and laboratory data were collected the day before surgery. Postoperative AKI included events occurring within 7 days of the index operation, and mortality was obtained during 3 years of follow‐up. Results: The ratio of postoperative AKI was 14.35% (31/216 patients). The urine NGAL level in group 1 was significantly higher than in group 2, p < 0.001. At cut‐off value = 14.94 ng/mL, uNGAL has a predictive value for AKI (area under the curve [AUC] = 0.858, p < 0.001). After 3 years of follow‐up, the total mortality rate was 7.9%. The mortality rate in group 1 (45.2%) was significantly higher than in group 2 (1.6%) with p < 0.001). At cut‐off value = 19.85 ng/mL, uNGAL has a predictive value for mortality (AUC = 0.941, p < 0.001). Conclusions: The rate of acute kidney injury after laparoscopic CRC surgery was 14.35%. Preoperative urine NGAL has a good predictive value for postoperative acute kidney injury and mortality during 3 years of follow‐up. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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