Impact of molecular status on clinical management in children with histiocytosis treated according to POL HISTIO project.

Autor: Raciborska, Anna, Małas, Zofia, Tysarowski, Andrzej, Seliga, Katarzyna, Machnik, Katarzyna, Wecławek-Tompol, Jadwiga, Derwich, Katarzyna, Rurańska, Iwona, Muszyńska-Rosłan, Katarzyna, Michalak, Elżbieta, Badowska, Wanda, Karolczyk, Grażyna, Chaber, Radosław, Drabko, Katarzyna, Rodriguez-Galindo, Carlos
Předmět:
Zdroj: Acta Haematologica Polonica; 2023, Vol. 54 Issue 5, p313-317, 5p
Abstrakt: The article focuses on rare histiocytic disorders characterized by abnormal cell proliferation linked to the RAS/MAPK signaling pathway. It introduces the classification of histiocytosis into five groups and highlights Langerhans cell histiocytosis (LCH) in children, with variations in severity. It emphasizes the role of molecular status, particularly BRAF mutations, in diagnosing and managing these disorders.
Databáze: Complementary Index