Synthesis, α-Glucosidase and β-Galactosidase Inhibitory Potentials and Molecular Docking of Some Novel Benzofuran-Pyridazine Derivatives.

Autor:	Boukharsa, Youness, Karrouchi, Khalid, Anouar, El Hassane, Albalwi, Hanan, Jarbi, Ibtissam, Ramli, Youssef, Faouzi, My El Abbes, Ansar, M'hammed
Předmět:	MOLECULAR docking GALACTOSIDASES BINDING sites ALPHA-glucosidases PYRIDAZINES CHEMICAL synthesis
Zdroj:	Polycyclic Aromatic Compounds; 2023, Vol. 43 Issue 9, p8482-8493, 12p
Abstrakt:	A novel series of benzofuran-pyridazine derivatives have been synthesized and characterized by different spectroscopic techniques including FT-IR, 1H-NMR, 13C-NMR, and ESI-MS spectrometry. All synthesized compounds were evaluated in vitro for their antidiabetic activity against α-glucosidase and β-galactosidase enzymes. All derivatives (3a-3h) and (4a-4b) showed a remarkable inhibitory potential greater than 89% against α-glucosidase enzyme compared to standard acarbose (42.50%), and compounds 3 b and 4a exhibited significant inhibitory potential against β-galactosidase enzyme with 50.33% and 57.67% respectively, compared to standard Queretin (52.00%). A molecular docking study was conducted to understand the binding interactions of the compounds with the active site of the α-glucosidase enzyme. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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