| Abstrakt: |
The objective of the present research was to evaluate camphene’s effects on doxorubicin-induced myocardial infarction (MI) in Wister albino rats. In affluent nations, the extension of human life is increasingly accompanied by a rise in cardiac complications, the majority of which have merely symptomatic treatments rather than effective therapies. Cardiac inflammation, oxidative stress, and apoptosis are presently proposed factors underlying the etiology of myocardial infarction or cardiotoxicity. Many medications against myocardial infarction have been created for the conduct of cardiotoxicity, but unfortunately, their possible adverse effects have caused physicians to seriously worry about their usage. In this direction, we, therefore, planned to explore the cardioprotective effect of camphene against Dox-encouraged myocardial infarction in Wister albino rats. Animals were separated into 5 groups: Normal control; Toxic (DOX 2 mg/kg); Camphene 100 + DOX [I]; Camphene 200 + DOX [II]; Resveratrol 20 + Dox. An amount of doxorubicin was given once every 48 hours for 12 days and after the last day of dosing, the weight of all animals was weighed individually before sacrificing the animals. On the 13th day, performed all biochemical parameters relating to Total antioxidant capacity (TAC), CK-MB and LDH were assessed in the blood after serum separation by homogenizer at 3000 RPM for 15 min. Apart from these parameters, other biochemical parameters including TBARS, GSH, Catalase and SOD were also performed to establish the cardioprotective effect of camphene. Body weight and histopathology were also measured. Our research ultimately indicated that camphene has a strong cardioprotective response against myocardial infarction caused by doxorubicin. [ABSTRACT FROM AUTHOR] |
